More recent publications

Google Scholar Profile

You can also visit my Google Scholar profile for information about publications. Same thing, sorted by year of publication, i.e. to see my recent publications.)

Techniques and miscellaneous

  • R. Salomon-Ferrer, D.A. Case and R.C. Walker. An overview of the Amber biomolecular simulation package. WIREs: Comput. Mol. Sci. 3, 198-210 (2013). (Figure shows the cover of the Amber Users' Manual)

  • J. Latzer, T. Steinbrecher and D.A. Case. Revised AMBER parameters for bioorganic phosphates. J. Chem. Theory Comput. 8, 4405-4412 (2012).

  • D.S. Cerutti, J.E. Rice, W. Swope, and D.A. Case. Derivation of fixed partial charges for amino acid analogs accommodating a specific water model and implicit polarization. J. Phys. Chem. B 117, 2328-2338 (2013).

  • D.S. Cerutti, W.C. Swope, J.E. Rice and D.A. Case. ff14ipq: A self-consistent force field for condensed-phase simulations of proteins. J. Chem. Theory Comput. 10, 4515-4534 (2014).

  • I. Ivani, P.D. Dans, A. Noy, A. Pérez, I. Faustino, A. Hopsital, J. Walther, P. Andrió, R. Goñi, A. Balaceanu, G. Portella, F. Battistini, J.L. Gelpí, C. González, M. Vendruscolo, C.A. Laughton, S. Harris, D.A. Case and M. Orozco. Parmbsc1: A refined force field for DNA simulations. Nature Methods 13, 55-58 (2016).

  • K.T. Debiec, D.S. Cerutti, L.R. Baker, A.M. Gronenborn, D.A. Case, and L.T. Chong. Further along the Road Less Traveled: AMBER ff15ipq, an Original Protein Force Field Built on a Self-Consistent Physical Model. J. Chem. Theory Comput. 12, 3926-3947 (2016).

  • Y. Hu, B. Sherborne, T.-S. Lee, D.A. Case, D.M. York and Z. Guo. Predicting relative binding affinity with workflow approaches: a comparison of AMBER TI and Schrödinger FEP.J. Comput. Aided Mol. Des. 30, 533-539 (2016).

  • A. Albaugh, R.T. Bradshaw, O. Demerdash, J. Dziedzic, Y. Mao, D.T. Margul, J. Swails, H.A. Boateng, D.A. Case, P. Eastman, J.W. Essex, M. Head-Gordon, V.S. Pande, J. Ponder, Y. Shao, C. Skylaris, I.T. Todorov, M.E. Tuckerman, Q. Zeng, T. Head-Gordon. Advanced Potential Energy Surfaces for Molecular Simulation. J. Phys. Chem. B 120, 9811-9821 (2016).

  • D.S. Cerutti, K.T. Debiec, D.A. Case and L.T. Chong. Links between the charge model and bonded parameter force constants in biomolecular force fields. J. Chem. Phys. 147, 161730 (2017).

  • T.-S. Lee, D.S. Cerutti, D. Mermelstein, C. Lin, S. LeGrand, T.J. Giese, A. Roitberg, D.A. Case, R.C. Walker, and D.M. York. GPU-accelerated molecular dynamics and free energy methods in Amber18: performance enhancements and new features. J. Chem. Inf. Model. 58, 2043-2050 (2018).

  • A.B. Rubenstein, K. Blacklock, H. Nguyen, D.A. Case and S.D. Khare. Systematic comparison of Amber and Rosetta energy functions for protein structure evaluation. J. Chem. Theory Comput. 14, 6015-6025 (2018).

  • A.T. Bogetti, H.E. Piston, J.M. G. Leung, C.C. Cabalteja, D.T. Yang, A.J. DeGrave, K.T. Debiec, D.S. Cerutti, D.A. Case, W.S. Horne, and L.T. Chong. A Twist in the Road Less Traveled: The AMBER ff15ipq-m Force Field for Protein Mimetics. J. Chem. Phys. 153, 064101 (2020).

  • D.A. Case, H.M. Aktulga, K. Belfon, D. Cerutti, G.A. Cisneros, V.W. Cruzeiro, N. Forouzesh, T. Giese, A. Götz, H. Gohlke, S. Izadi, K. Kasavajhala, M. Kaymak, E. King, T. Kurtzman, T. Lee, P. Li, J. Liu, T. Luchko, R. Luo, M. Machado, M. Manathunga, H. Nguyen, K. O'Hearn, A. Onufriev, F. Pan, S. Pantano, R. Qi, A. Rahnamoun, A. Risheh, S. Schott-Verdugo, A. Shajan, J. Swails, J. Wang, H. Wei, X. Wu, Y. Wu, S. Zhang, S. Zhao, Q. Zhu, T. Cheatham, D.R. Roe, A. Roitberg, C. Simmerling, D. York, M. Nagan, and K. Merz. AmberTools. J. Comput. Inf. Model. 63, 6183-6191 (2023).


    Structure and dynamic analysis using X-ray and cryo-EM data

  • L. Moulinier, D.A. Case and T. Simonson. Re-introducing electrostatics into protein X-ray structure refinement: bulk solvent treated as a dielectric continuum. Acta Cryst. D 59, 2094-2103 (2003). (Figure shows a piece of X-ray density using an implicit solvent refinement model.)

  • D.S. Cerutti, P.L. Freddolino, R.E. Duke, Jr. and D.A. Case. Simulations of a protein crystal with a high resolution X-ray structure: Evaluation of force fields and water models. J. Phys. Chem. B 114, 12811-12824 (2010).

  • P.A. Janowski, D.S. Cerutti, J. Holton and D.A. Case. Peptide crystal simulations reveal hidden dynamics. J. Am. Chem. Soc. 135, 7938-7948 (2013).

  • X. Wu, S. Subramaniam, D.A. Case, K. Wu and B.R. Brooks. Map constrained self-guided Langevin dynamics. J. Struct. Biol. 183, 429-440 (2013).

  • H. Nguyen, S.A. Pabitt, S. Meisburger, L. Pollack and D.A. Case. Accurate small and wide angle X-ray scattering profiles from atomic models of proteins and nucleic acids. J. Chem. Phys. 114, 22D508 (2014).

  • C. Liu, P.A. Janowski and D.A. Case. All-atom crystal simulations of DNA and RNA duplexes. Biochim. Biophys. Acta 1850, 1059-1071 (2015).

  • P.A. Janowski, C. Liu and D.A. Case. Molecular dynamics of triclinic lysozyme in a crystal lattice. Prot. Sci. 25, 87-102 (2016).

  • H.T. Nguyen, S.A. Pabit, L. Pollack and D.A. Case. Extracting water and ion distributions from small angle X-ray scattering experiments. J. Chem. Phys. 144, 214105 (2016).

  • P.A. Janowski, N.W. Moriarty, B.P. Kelly, D.A. Case, D.M. York, P.D. Adams and G.L. Warren. Phenix-AFITT: Improved ligand geometries in crystallographic refinement using AFITT in Phenix. Acta Cryst. D 72, 1062-1072 (2016).

  • K. Zhang, S. Keane, Z. Su, R.N. Irobalieva, M. Chen, J. Marchant, X. Heng, M.F. Schmid, D.A. Case, S.J. Ludtke, M.F. Summers and W. Chiu. Structure of the 30 kDa HIV-1 RNA Dimerization Signal by a Hybrid of CryoEM, NMR and Molecular Dynamics. Structure 26, 490-498 (2018).

  • D.S. Cerutti and D.A. Case. Molecular dynamics simulations of macromolecular crystals. Wires Comput. Mol. Sci. e1402, (2018).

  • N.W. Moriarty, P.A. Janowski, J.M. Swails, H. Nguyen, J.S. Richardson, D.A. Case and P.D. Adams. Improved chemistry restraints for crystallographic refinement by integrating Amber molecular mechanics into Phenix. Acta Cryst. D76, 51-62 (2020).

  • S.P. Meisburger, D.A. Case and N. Ando. Correlated motions in a protein crystal. Nature Commun. 11, 1271 (2020).

  • J.G. Gray and D.A. Case. Refinement of RNA structures guided by the Amber force field. Crystals 11, 771 (2021).

  • S.J. Budiardjo, J.J. Stevens, A.L. Calkins, A.P. Ikujuni, V.K. Wimalasena, E. Firlar, D.A. Case , J.S. Biteen, J.T. Kaelber and J.S.G. Slusky. Colicin E1 binds to TolC as an open hinge to penetrate the outer-membrane. eLife 11, e73297 (2022).

  • S.P. Meisburger, D.A. Case and N. Ando. Robust total X-ray scattering workflow to study correlated motion of proteins in crystals. Nature Commun. 14, 1228 (2023).

  • D.A. Case. MD Simulations of macromolecular crystals: Implications for the analysis of Bragg and diffuse scattering. Meth. Enzymol. 688, 145-168 (2023).

  • O. Mikhailovskii, S.A. Izmailov, Y. Xue, D.A. Case, and N.R. Skrynnikov. X-ray crystallography module in the Amber 2023 simulation program. Refining the models of protein crystals. J. Comput. Inf. Model. 64, 18-25 (2024).


    Structure and dynamic analysis using NMR data -- methods

  • V. Wong, D.A. Case and A. Szabo. Influence of the coupling of interdomain and overall motions on NMR relaxation. Proc. Natl. Acad. Sci. USA 101, 11016-11021 (2009).

  • B.S. Tolbert, Y. Miyazaki, S. Barton, B. Kinde, P. Starck, R. Singh, A. Bax, D.A. Case, and M.F. Summers. Major groove width variations in RNA structures determined by NMR and impact of 13C residual chemical shift anisotropy and 1H--13C residual dipolar coupling on refinement. J. Biomol. NMR 47, 205-219 (2010).

  • J. Xia, C.J. Margulis and D.A. Case. Searching and optimizing structure ensembles for complex flexible sugars. J. Am. Chem. Soc. 133, 15252-15255 (2011). (Figure shows some selected ensembles of simple sugars.)

  • J. Xia and D.A. Case. Sucrose in aqueous solution revisited. 1. Molecular dynamics simulations and direct and indirect dipolar coupling analysis. Biopolymers, 97, 276-288 (2012).

  • J. Xia and D.A. Case. Sucrose in aqueous solution revisited. 2. Adaptively biased molecular dynamics simulations and computational analysis of NMR relaxation. Biopolymers, 97, 289-302 (2012).

  • H. Zhang, G. Hou, M. Lu, J. Ahn, I.-J. Byeon, C.J. Langmead, J.R. Perilla, I. Hung, P.L. Gor’kov, Z. Gan, W. Brey, D.A. Case, K. Schulten, A.M. Gronenborn, and T. Polenova. HIV-1 Capsid Function is Regulated by Dynamics: Quantitative Atomic-Resolution Insights by Integrating Magic-Angle-Spinning NMR, QM/MM, and MD. J. Am. Chem. Soc. 138, 14066-14075 (2016).

  • D.A. Case and N.R. Skrynnikov. Interview with David A. Case: on force fields, biomolecular modeling, and NMR. Concepts Magn. Reson. Part A e21403 (2018).

  • H. Nam, O. Becette, R.M. LeBlanc, D.S. Oh, D.A. Case, and T.K. Dayie. Deleterious effects of carbon-carbon dipolar coupling on RNA NMR dynamics. J. Biomol. NMR 74, 321-331 (2020).

  • E. Zuiderweg and D.A. Case. New experimental evidence for pervasive dynamics in proteins. Prot. Sci. 32, e4630 (2023).


    Structure refinement using NMR data -- structures

  • Q. Zhang, T. Dwyer, V. Tsui, D. Case, J. Cho, P.B. Dervan and D.E. Wemmer. NMR structure of a cyclic polyamide-DNA complex. J. Am. Chem. Soc. 126, 7958-7966 (2004). (Figure shows a superposition of NMR structures for this complex.)

  • G.M. Giambasu, D.M. York and D.A. Case. Structural fidelity and NMR relaxation analysis in a prototype RNA hairpin. RNA 21, 963-974 (2015).

  • S.C. Keane, X. Heng, K. Lu, S. Kharytonchyk, V. Ramakrishnan, G. Carter, S. Barton, A. Hosic, A. Florwick, J. Santos, N. Bolden, S. McCowin, D.A. Case, B. Johnson, M. Salemi, A. Telesnitsky, and M.F. Summers. Structure of the HIV-1 RNA packaging signal. Science, 348, 917-921 (2015).

  • L. Salmon, G.M. Giambasu, E.N. Nikolova, K. Petzold, A. Bhattacharya, D.A. Case and H.M. Al-Hashimi. Modulating RNA Alignment Using Directional Dynamic Kinks: Application in Determining an Atomic-Resolution Ensemble for a Hairpin using NMR Residual Dipolar Couplings. J. Am. Chem. Soc. 137, 12954-12965 (2015).

  • C.-H. Hsu, S. Park, D.E. Mortenson, B.L. Foley, R.J. Woods, D.A. Case, E.T. Powers, C.-H. Wong, H.J. Dyson and J.W. Kelly. The Dependence of Carbohydrate--Aromatic Interaction Strengths on the Structure of the Carbohydrate. J. Am. Chem. Soc. 138, 7636-7648 (2016).

  • J.J. Bouchard, J. Xia, D.A. Case and J.W. Peng. A new approach for ensemble descriptions of interdomain motions: application to Pin1. J. Mol. Biol. 430, 2164-2180 (2018).

  • M. Zhang, D.A. Case, and J.W. Peng. Propagated perturbations from a peripheral mutation map interactions supporting WW domain thermostability. Structure 26, 1474-1485 (2018).

  • J.D. Brown, S. Kharytonchyk, A.S. Iyer, H. Carter, Y. Desai, L. Glang, S.H. Choi, M.W. Lopresti, I. Chaudry, K. Singh, M. Orellana, T. Rodriguez, U. Oboh, J. Hijji, F.G. Ghinger, K. Stewart, G. Becker, D. Francis, B. Edwards, P. Chen, D.A. Case, A. Telesnitsky, and M.F. Summers. Structural Basis for Transcriptional Start Site Control of HIV-1 RNA Fate. Science 368, 413–417 (2020).

  • M. Zhang, T.E. Frederick, D.A. Case, J.W. Peng. Coupled intra-and interdomain dynamics support domain cross-talk in Pin1. J. Biol. Chem. 295, 16585-16603 (2020).

  • H. Shi, A. Rangadurai, H.A. Assi, R. Roy, D.A. Case, D. Herschlag, J.D. Yesselman, and H.M. Al-Hashimi. Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction. Nature Commun. 11, 5531 (2020).

  • B. Liu, H. Shi, A. Rangadurai, C.-C. Chu, F. Nussbaumer, K.A. Erharter, D.A. Case, C. Kreutz, and H.M. Al-Hashimi. m6A delays base-pairing through syn-anti isomerization of the methylamino group. Nature Commun. 12, 1-17 (2021).

  • A. Geng, L. Ganser, R. Roy, S. Pratihar, D.A. Case, and H.M. Al-Hashimi. An RNA excited conformational state at atomic resolution. Nature Commun. 14, 8432 (2023).


    Analysis of chemical shifts and coupling constants in proteins and nucleic acids

  • S. Tang and D.A. Case. Vibrational averaging of chemical shift anisotropies in model peptides. J. Biomol. NMR. 38, 255-266 (2007).

  • S. Tang and D.A. Case. Calculation of chemical shift anisotropy in proteins. J. Biomol. NMR 51, 303-312 (2011).

  • D.A. Case. Chemical shifts in biomolecules. Curr. Opin. Struct. Biol. 23, 172-176 (2013).

  • J. Swails, T. Zhu, X. He and D.A. Case. AFNMR: Automated fragment quantum mechanical calculations of chemical shifts in biomolecules. J. Biomol. NMR 63, 125-139 (2015).

  • J. Kraus, R. Gupta, J. Yehl, M. Lu, D.A. Case, A.M. Gronenborn, M. Akke, and T. Polenova. Chemical Shifts of the Carbohydrate Binding Domain of Galectin-3 from Magic Angle Spinning NMR and Hybrid Quantum Mechanics/Molecular Mechanics Calculations. J. Phys. Chem. B 122, 2931-2939 (2018).

  • M. Fritz, C.M. Quinn, M. Wang, G. Hou, X. Lu, L.M.I. Koharudin, J. Struppe, D.A. Case, T. Polenova and A.M. Gronenborn. Accurate determination of backbone chemical shift tensors in microcrystalline proteins by integrated MAS NMR and QM/MM. Phys. Chem. Chem. Phys. 20, 9543-9553 (2018).

  • H. Shi, M.C. Clay, A. Rangadurai, B. Sathyamoorthy, D.A. Case, and H.M. Al-Hashimi. Atomic Structures of Excited State A-T Hoogsteen Base Pairs in Duplex DNA by Combining NMR Relaxation Dispersion, Mutagenesis, and Chemical Shift Calculations. J. Biomol. NMR 70, 229-244 (2018).

  • H. Zhou, B. Sathyamoorthy, A. Stelling, Y. Xu, Y. Xue, Y.Z. Pigli, D.A. Case, P.A. Rice, and H.M. Al-Hashimi. Characterizing Watson–Crick versus Hoogsteen Base Pairing in a DNA–Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C-and 15N-Labeled DNA. Biochemistry,58, 1963-1974 (2019).

  • D.A. Case. Using quantum chemistry to estimate chemical shifts in biomolecules. Biophys. Chem. 267, 106476 (2020).

  • O.B. Becette, G. Zong, B. Chen, K.M. Taiwo, P.Y. Zavalij, D.A. Case and T.K. Dayie. Solution NMR Readily Reveals Structural Folds and Interactions in Doubly Carbon-13 and Fluorine-19 Labeled RNAs. Sci. Adv. 6, eabc6572 (2020).

  • F. Juen, D. Glänzer, R. Plangger, V. Kugler, J. Fleischmann, E. Stefan, D.A. Case, H. Kovacs, T.K. Dayie, C. Kreutz. Enhanced TROSY effect in [2-19F, 2-13C] adenosine and ATP analogs facilitates NMR spectroscopy of very large biological RNAs in solution. Angew. Chemie 136, e202316273 (2024).


    Electrostatic interactions in biomolecules

  • A. Onufriev, D.A. Case and G.M. Ullmann. A novel view of pH titration in biomolecules. Biochemistry 40, 3413-3419 (2001).

  • N.A. Baker, D. Bashford and D.A. Case. Implicit solvent electrostatics in biomolecular simulation. In New Algorithms for Macromolecular Simulation, B. Leimkuhler, C. Chipot, R. Elber, A. Laaksonen, A. Mark, T. Schlick, C. Schütte, and R. Skeel, eds. (New York: Springer-Verlag, 2006), pp. 263-295.

  • T. Luchko, S. Gusarov, D.A. Case, J. Tuszynski and A. Kovalenko. Three-dimensional molecular theory of solvation coupled with molecular dynamics in Amber. J. Chem. Theory Comput. 6, 607-624 (2010)

  • T. Luchko, I.S. Joung and D.A. Case. Integral equation theory of biomolecules and electrolytes. In: Innovations in Biomolecular Modeling and Simulation, T. Schlick, ed. (London, Royal Society of Chemistry, 2012), pp. 51-86.

  • I.S. Joung, T. Luchko and David A. Case. Simple electrolyte solutions: Comparison of RISM and molecular dynamics results for alkali halide solutions. J. Chem. Phys. 138, 044103 (2013).

  • G.M. Giambasu, T. Luchko, D. Herschlag, D.M. York and D.A. Case. Ion counting from explicit solvent simulations and 3D-RISM. Biophys. J. 104, 883-894 (2014). (Figure shows sodium ion distributions around a DNA base pair.)

  • G.M. Giambasu, M.K. Gebala, M.T. Panteva, D.A. Case, D. Herschlag and D.M. York. Competitive interaction of monovalent cations with DNA predicted by 3D-RISM. Nucl. Acids Res. 43, 8405-8415 (2015).

  • J. Johnson, D.A. Case, T. Yamazaki, S. Gusarov, A. Kovalenko and T. Luchko. Small Molecule Solvation Energy and Entropy from 3D-RISM. J. Phys. Cond. Mat. 28, 344002 (2016).

  • G.M. Giambasu, D.A. Case, D.M. York. Predicting site-binding modes of ions and water to nucleic acids using molecular solvation theory. J. Am. Chem. Soc. 141, 2435-2445 (2019).

  • C. Nguyen, T. Yamazaki, A. Kovalenko, D.A. Case, M.K. Gilson, T. Kurtzman, and T. Luchko. A molecular reconstruction approach to site-based 3D-RISM and comparison to GIST hydration thermodynamic maps in an enzyme active site. PLoS One 14, e0219473 (2019).

  • A.V. Onufriev and D.A. Case. Generalized Born implicit solvent models for biomolecules. Annu. Rev. Biophys. 48, 275-296 (2019).

  • J.G. Gray, G.M. Giambaşu, D.A. Case and T. Luchko. Integral equation models for solvent in macromolecular crystals. J. Chem. Phys. 156, 014801 (2022).

    Dynamics of peptides and proteins

  • A.P. Graves, D.M. Shivakumar, S.E. Boyce, M.P. Jacobson, D.A. Case and B. Shoichet. Rescoring docking hit lists for model cavity sites: predictions and experimental testing. J. Mol. Biol. 377, 914-934 (2008).

  • M.C. Thielges, D.A. Case and F.E. Romesberg. Carbon-deuterium bonds as probes of electrostatics in dihydrofolate reductase. J. Am. Chem. Soc. 130, 6597-6603 (2008).

  • A.A. Fuller, D. Du, F. Liu, J.E. Davoren, G. Bhabha, G. Kroon, D.A. Case, H.J. Dyson, E.T. Powers, P. Wipf, M. Gruebele, and J.W. Kelly. Evaluation of β-sheet folding nucleation kinetics by β-turn mimics. Proc. Natl. Acad. Sci. USA 101, 11067-11072 (2009).

  • R. Chaudhuri, S. Tang, G. Zhao, H. Lu, D.A. Case and M.E. Johnson. Comparison of SARS and NL63 papain-Like protease binding sites and binding site dynamics: Inhibitor design implications. J. Mol. Biol. 414, 272-288 (2011). (Figure shows the electrostatic surface of the SARS-CoV PLpro protease.)

  • I. Fu, D.A. Case and J. Baum. Dynamic water-mediated hydrogen bonding in collagen model peptides. Biochemistry 54, 6029-6037 (2015).

  • C.L. Hoop, J. Zhu, A.M. Nunes, D.A. Case and J. Baum. Revealing accessibility of cryptic protein binding sites within the functional collagen fibril. Biomolecules 7, 76 (2017).

  • J. Zhu, C. Hoop, D.A. Case, and J. Baum. Surface Reconstruction of the Type I Collagen Fibril Exposes Cryptic Binding Sites. Sci. Reports 8, 16646 (2018).

  • C.L. Hoop, A. Kemraj, B. Wang, S. Gahlawat, M. Godesky, J. Zhu, H.R. Warren, D.A. Case, D.I. Shreiber, and J. Baum. Molecular underpinnings of integrin binding to vascular Ehlers-Danlos Syndrome collagen mimetics. J. Biol. Chem. 294, 14442-14453 (2019).

  • P.P. Samuel, M.A. White, W.C. Ou, D.A. Case, G.N. Phillips, Jr., and J.S. Olson. The interplay between molten globules and heme disassociation defines human hemoglobin disassembly. Biophys. J. 118, 1381-1400 (2020).

  • P.P. Samuel and D.A. Case. Atomistic simulations of heme disassociation pathways in human methemoglobins reveal hidden intermediates. Biochemistry 59, 4093-4107 (2020).

  • J.K. Williams, B. Wang, A. Sam, C.L. Hoop, D.A. Case and J. Baum. Molecular Dynamics Analysis of a Flexible Loop Near the Binding Interface of the Spike Protein Receptor-Binding Domain from SARS-CoV-2. Proteins, DOI: 10.1002/prot.26208 (2021).

  • R.D. Palmere, D.A. Case and A.J. Nieuwkoop. Cooperative Effects of Phosphatidyl Inositol Phosphate Protonation State on the PIP Binding Kindlin-2 Subdomains. Biophys J. 120, 5504-5512 (2021).

  • E.R.P. Zuiderweg, D.A. Case and C.H. Williams, Jr. Simulating the motion underlying the mechanism of thioredoxin reductase. ACS Omega 9, 29682-29690 (2024).


    DNA/RNA Secondary and Tertiary Structure

  • V. Tsui, T. Macke, and D.A. Case. A novel method for finding tRNA genes. RNA 9, 507-517 (2003). (Figure shows a "descriptor" for finding tRNA genes in prokaryotes.)

  • F.-Y. Dupradeau, D.A. Case, C. Yu, R. Jimenez and F.E. Romesberg. Differential solvation and tautomer stability of a model base pair withing the minor and major groove of DNA. J. Am. Chem. Soc. 127, 15612-15617 (2005).

  • D.H. Mathews and D.A. Case. Nudged Elastic Band calculation of minimal energy pathways for the conformational change of a GG mismatch. J. Mol. Biol. 357, 275-291 (2006).

  • Y. Bomble and D.A. Case. Multiscale modeling of nucleic acids: Insights into DNA flexibility. Biopolymers, 89, 722-731 (2008).

  • T.E. Cheatham, III and D.A. Case. Twenty-five years of nucleic acid simulations. Biopolymers 99, 969-977 (2013).

  • M. Pasi, J.H. Maddocks, D. Beveridge, T.C. Bishop, D.A. Case, T. Cheatham III, B. Jayaram, F. Lankas, C. Laughton, J. Mitchel, R. Osman, M. Orozco, D. Petkeviciute, N. Spackova, J. Sponer, K. Zakrzewska and R. Lavery. μABC: a systematic microsecond molecular dynamics study of tetranucleotide sequence effects in B-DNA. Nucl. Acids Res. 42, 12272-12283 (2014).

  • S. Ekesan, E. McCarthy, D.A. Case and D.M. York. RNA electrostatics: How ribozymes engineer active sites to enable catalysis. J. Phys. Chem. B 126, 5982-5990 (2022).


    Active sites of iron-sulfur (and Mn-O) proteins

  • J.A. Fee, J.M. Catagnetto, D.A. Case, L. Noodleman, C.D. Stout and R.A. Torres. The circumsphere as a tool to assess distortion in [4Fe-4S] atom clusters. J. Biol. Inorg. Chem. 8, 519-526 (2003). (Figure shows a geometric analysis of these cubane systems.)

  • Y. Xiao, K. Fisher, M.C. Smith, W.E. Newton, D.A. Case, S.J. George, H. Wang, W. Sturhahn, E.E. Alp, J. Zhao, Y. Yoda and S.P. Cramer. How nitrogenase shakes--initial information about P-cluster and FeMo-cofactor normal modes from nuclear resonance vibrational spectroscopy (NRVS). J. Am. Chem. Soc. 128, 7608-7612 (2006).

  • Y. Guo, H. Wang, Y. Xiao, S. Vogt, R.K. Thauer, S. Shima, P.I. Volkers, T.B. Rauchfuss, V. Pelmentschikov, D.A. Case, E.E. Alp, W. Sturhahn, Y. Yoda, and S.P. Cramer. Characterization of the Fe Site in Methanothermobacter marburgensis Hydrogenase (mHmd) and a Model Compound via Nuclear Resonance Vibrational Spectroscopy (NRVS). Inorg. Chem. 47, 3969-3977 (2008).

  • J.A. Fee, D.A. Case and L. Noodleman. Toward a mechanism of proton pumping by the B-type cytochrome c oxidases: Application of density functional theory to cytochrome ba3 from Thermus thermophilus. J. Am. Chem. Soc. 130, 15002-15021 (2008).

  • V. Pelmenschikov, Y. Guo, H. Wang, S.P. Cramer and D.A. Case. Fe-H/D stretching and bending modes in nuclear resonant vibrational, Raman and infrared spectroscopies: Comparisons of density functional theory and experiment. Faraday Disc. 148, 409-420 (2011).

  • D. Mitra, V. Pelmenschikov, Y. Guo, D.A. Case, H. Wang, W. Dong, M. Tan, T. Ichiye, F. Jenney, Jr., M.W.W. Adams, M. Kaupp and S.P. Cramer. Dynamics of the [4Fe-4S] Cluster in Pyrococcus furiosus Ferredoxin via Nuclear Resonance Vibrational Spectroscopy (NRVS) and Resonance Raman Spectroscopy – Quantitative Simulation by Density Functional Theory. Biochemistry 50, 5220-5235 (2011).

  • J.D. Kim, A. Godriguez-Ganillo, D.A. Case, V. Nanda and P.G. Falkowski. Energetic selection of topology in ferredoxins. PLoS Comput. Biol. 8, e1002463 (2012).

  • D. Mitra, S. George, J. Peters, S. Keable, V. Pelmenschikov, D.A. Case, and S.P. Cramer. Dynamics of the [4Fe-4S] cluster in Azotobacter vinelandii nitrogenase Fe protein in three core oxidation states via nuclear resonance vibrational spectroscopy (NRVS). J. Am. Chem. Soc. 135, 2530-2543 (2013).

  • H. Chen, G.C. Dismkes and D.A. Case, Resolving Ambiguous Protonation and Oxidation States in the Oxygen Evolving Complex of Photosystem II . J. Phys. Chem. B 122, 8654-8664 (2018).

  • H. Chen, D.A. Case and G.C. Dismukes. Reconciling Structural and Spectroscopic Fingerprints of the Oxygen Evolving Complex of Photosystem II: A Computational Study of the S2 State. J Phys. Chem. B, 122, 11868-11882 (2018).

  • V. Hoeke,L. Tociu, D.A. Case, L.C. Seefeldt, S. Raugei, and B.M. Hoffman. High resolution ENDOR spectroscopy combined with quantum chemical calculations reveals the structure of the nitrogenase Janus intermediate E4(4H). J. Am. Chem. Soc. 130, 11984-11996 (2019).



    Updated on October 3, 2024. Comments to david.case@rutgers.edu